A new study published in the scientific journal Physics of Fluids showed that body position has a significant impact on the effectiveness of pills.
Scientists at the US Johns Hopkins University created a computer simulation based on MRI observation of how pills dissolve in the stomach. Four different postures were studied. These postures included standing upright, lying on your back, and lying to the right or left.
In general, the time it takes for a pill to start affecting the body is typically typical depending on the pill’s makeup and chemical components. It ranges from 15 minutes to an hour.
— Pill Lying on the right side after drinking made the pill dissolve in 10 minutes. This option was the best. Leaning to your right at an angle of about 45 degrees greatly accelerates the rate at which a pill dissolves and enters the duodenum.
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— In the second row was standing upright.
— The third place was lying on the back. In both stops, the time was up to 23 minutes.
— For those extending to the left if the pill dissolves completely 1.5 hours passed. Researchers think that the reason for this difference is the anatomical structure of the stomach and gravity.
Senior author Rajat Mittal, professor of mechanical engineering and biomechanics at Johns Hopkins, said Rajat Mittal, “It’s surprising that body posture can have such an impact on the rate of dissolution of the pill. This will come to mind every time I take a pill from now on.” He said that the results of this research may be important in the care of elderly or bedridden people.
While taking the pill, other factors come to the fore as well as the position of the body. Alright medicine while drinking What mistakes do we make the most?
–Can we take the medicine with other liquids other than water?
Can every pill be chewed?
–Can drugs be divided into two and taken?
–Is there a problem when only the inside of the capsule pills is consumed?
What should those who have difficulty in taking pills do?
Gastroenterology specialist Doctor, Faculty Member Özdal Ersoy He explained why the posture of the body is so effective:
“Our filled organs such as the heart, liver, and spleen, which are above or below the diaphragm, are not symmetrically located on the right and left sides of our body. As the body position changes, the mechanical pressures these organs create on our stomach and intestines, which are our hollow organs, change. Again, the fluids in our stomach and intestines, which are hollow organs, are also affected by gravity to different degrees depending on body position. When lying on the left side, since the stomach is on the left, it expands easily with the decrease in the effect of gravity, but the emptying time of the stomach is prolonged because the stomach liquids or food will move less in the stomach. This results in a mechanical effect that will relax the stomach muscles and reduce stomach movements. This prolongs the dissolution and absorption times of the capsule drugs we take.”
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Ersoy stated that when the person is standing or lying on his right side, since the expansion of the stomach may be less due to the pressure of the liver, which is the neighboring organ of the stomach, and this situation is accompanied by gravity when standing, the stomach contents are pushed into the small intestine with rapid movements and in a short time, these mechanical movements also make the capsules faster. He said it would help solve it.
MOVING AFTER SWALLOWING PILLS INCREASES DRUG ABSORPTION
Stating that the passage of stomach contents to the intestine is accelerated in a person lying on the right after taking the drug, the drugs in the small intestine will be absorbed quickly. Gastroenterologist Prof. Dr. Cengiz PataHe added that the fact that we move after taking the medicine also accelerates the absorption.
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DOES LATER DISCLOSURE MEAN LATE EFFECT?
For example, we took a painkiller and slept on the left side. Does this mean our pain will go away after 100 minutes?
Ersoy states that the duration of action of drugs depends on many factors, one of these factors is the body position after taking the drug.
Ersoy said that the recommendations of the physicians are mostly as “Take your medicine with plenty of water, take the medicine with water, dissolve the tablet” or do not lie down for 30 minutes after taking it, do not sit, do not lie down’, but the main problem is generally the body position in taking the medicine by rote without consulting the physician. stated that non-compliance with the recommendations may adversely affect the onset times of the effectiveness of the drugs. He emphasized that awareness should be created and the society should be informed about this issue.
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Underlining that the way the drugs are taken is extremely important for their absorption, Pata said; He added that drugs can be in the form of liquid, granules, powder, granules, capsules and tablets, and that the size of the drug molecule, its ability to dissolve in water or oil, and whether it is acidic or basic affect drug absorption.
IF IT IS NOT WRITTEN ON THE PROSPECTUS, DO NOT SWITCH THE MEDICINE, DO NOT REMOVE IT FROM THE CAPSULE
Especially there are people who cannot swallow capsule pills. They take it out of the capsule and drink the powder, but is it healthy to consume like this or does it reduce the effect of the pill?
Ersoy said that removing the capsule and drinking the powdered medicine with water is not the right approach because the effectiveness of some medicines is adversely affected by saliva and stomach secretions.
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“The main active ingredient of the drug should be protected with a capsule or a coating material that protects it from stomach acid until the drug passes from the stomach to the small intestine. The effectiveness of the drug may decrease when the capsule is poured into the mouth or into the water and drunk.”
“The drug form is created according to the properties of the active substance of the drug. For example, basic drugs that will be destroyed in an acidic environment are wrapped in capsules so that they pass through the stomach without being affected, or drugs that are affected by stomach acid and need to be absorbed from the pre-metabolite are prepared in the form of tablets. Pata said, that’s why we should drink our medicines as they are.
Chewing and swallowing some pills can lead to poisoning. Which pills should not be chewed or crushed into powder?
Stating that there are drugs that are intended to dissolve only in the small intestine after ingestion, these drugs can only dissolve with the small intestine fluids, Ersoy said, “When these drugs are broken, crushed or drunk by breaking their integrity, the drug may cause harm rather than benefit because when these types of drugs are consumed by crushing or breaking, they cannot reach the small intestine. He said that the active substance would spread beforehand and reduce its effectiveness, so the drug would be wasted.
In summary, Ersoy strongly emphasizes that drugs should not be crushed, crushed, or powdered to be drunk or sucked unless there is a statement that they can be drunk by being melted or broken in their package inserts.
Gastroenterology Specialist Dr. Sule Namli Koc It is also noted that some drugs are covered with dragee because they are broken down very quickly by stomach acid, or they are covered with capsules and capsules. film He stated that they are in the form of tablets and that these drugs should be taken without chewing and with plenty of water.
RamHe also stated that the drugs should be swallowed without splitting in order to be exposed to stomach acid, because the divided drug taken can harm the person by increasing the stomach acid. For this reason, Koç stated that it is not correct to swallow the drugs by breaking up or taking them out of the capsule.
Stating that integrity is extremely important in the absorption of drugs, Pata stated that the first pass effect is that the drug loses its effect before it is absorbed, absorbed or before it enters the systemic circulation. He added that it will reduce its absorption, which may inevitably lead to inadequate treatment.
BEVERAGES OTHER THAN WATER REDUCES THE EFFECT OF THE DRUG
There are also those who prefer carbonated drinks or hot drinks such as coffee and tea, other than water, to swallow the pill. What are the harms of such consumption?
Ersoy answered our question with the following words:
“Medicines should be taken with water with neutral acidity. Since both the acidity and temperature of coffee, tea and carbonated beverages are different from water, they can disrupt the pharmacodynamics of drugs. Drinking drugs with hot or cold carbonated or non-carbonated beverages other than water may reduce the effectiveness of the drug, and may cause local side effects (such as ulcers and bleeding) by adhering to the mucous membranes of the digestive system.
- Medicines should be taken as indicated in their package inserts, if possible.
- Drinking with plenty of water prevents the drug from sticking and damaging especially the esophagus and stomach wall.
- Especially when the drugs are swallowed without water, the risk of getting stuck in the throat or esophagus develops.
- Especially some antibiotics, drugs containing calcium and its derivatives used for osteoporosis, or drugs containing potassium should not be drunk without water. If possible, it is recommended not to lie down for a while after swallowing the drugs.
Doctor, Faculty Member Özdal Ersoy
- Medicines should be taken as indicated in their package inserts, if possible.
- Drinking with plenty of water prevents the drug from sticking and damaging especially the esophagus and stomach wall.
- Especially when the drugs are swallowed without water, the risk of getting stuck in the throat or esophagus develops.
- Especially some antibiotics, drugs containing calcium and its derivatives used for osteoporosis, or drugs containing potassium should not be drunk without water. If possible, it is recommended not to lie down for a while after swallowing the drugs.
Doctor, Faculty Member Özdal Ersoy
HOW DO I SWALLOW THE DRUG?
Stating that food in the stomach does not absorb drugs, the protrusions called villi in the small intestines and the cells on it provide absorption, and that this area is about the size of two football fields (about 200 m²), Pata said that there are also rare drugs that do not comply with this generalization, that the stomach contents are the most acidic in the body. Pata said that taking these drugs on an empty stomach has a very damaging effect and emphasized that everyone should be careful in this regard.
IF YOU DRINK THROUGH IT CAN CLOSE TO THE FEAST PIPE
When some drugs are taken without water food Stating that it can stick to his pipe and cause serious pain and bleeding by causing wounds in that area, Koç said that there are also those who prefer carbonated drinks or hot drinks such as coffee and tea to swallow the pill, other than water. He conveyed the harms of consumption in this way with the following words:
“Milk and dairy products reduce the absorption of drugs and antibiotics in general. Caffeine in alcohol, tea and coffee also neutralizes these drugs. For this reason, it is recommended to take the drugs with plenty of water in general. If these rules are not followed, some antibiotics of the tetracycline group and other drugs can be inserted into the esophagus. For this reason, it is necessary to pay attention to drinks while taking pills.
Pata also stated that when some antibiotics are taken with milk, they can not bind to milk proteins or be absorbed, and that water is the ideal beverage to be used while swallowing medication, since it is a neutral and protein-free liquid. He reminded that it is extremely important to drink the drugs with plenty of water and your doctor’s warnings on how to take the drug, and added:
“Taking the drug with plenty of water will also prevent kidney damage. More importantly, we know that some drugs cause ulcers and mucosal damage by adhering to the gastrointestinal tract. These types of drugs should be taken with plenty of water so that they do not stick to the esophagus. In order to reduce the stomach effect, it should be taken fast.”
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